Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients

Recently, we have shown that two alleles of the glycoprotein (GP) la gene, designated C-807 and T-807, are associated with low or high platelet GPIa-I Ia density and consequently with slower or faster rate of platelet adhesion to type I collagen, respectively. This polymorphism could therefore presen t a genetic predisposition for the development of thrombotic disease and he mostasis. We investigated the relationship of the GPIa C807T dimorphism to the risk of coronary artery disease (CAD) and myocardial infarction (MI). A n allele-specific polymerase chain reaction (PCR) was developed for genotyp ing of C807T polymorphism. DNA samples from 2237 male patients who underwen t coronary angiography on account of coronary heart disease as verified ill ness or presumptive diagnosis were genotyped. The odds ratio was calculated as an estimate of the relative risk by multiple logistic regression. We fo und a strong association between the T allele and nonfatal MI among individ uals younger than the mean age of 62 years (n = 1,057; odds ratio, 1.57; P = .004). The odds ratio of MI increased for T-807 carriers with decreasing age. The highest odds ratio was detected within the youngest 10% of the stu dy sample (<49 years; n = 223; odds ratio, 2.61; P = .009). In contrast, no evidence of an association between C807T dimorphism with CAD was found. Ou r findings suggest that inherited platelet GP variations might have an impo rtant impact on acute thrombotic disease. (C) 1999 by The American Society of Hematology.