Three AML patients with existing or pre-existing intracerebral granulocytic sarcomas who were successfully treated with allogeneic bone marrow transplantations

We report three acute myelogenous leukemia (AML) patients who developed int racerebral granulocytic sarcomas (GS) and were successfully treated with al logeneic BMT (allo-BMT). The diagnosis of one patient was AML M2 with myelo fibrosis, and the other two patients were AML M4 with eosinophilia (AML M4 Eo), according to the FAB classification. Two patients first experienced a relapse in the brain that resulted in the formation of GS, followed by a re lapse in the bone marrow. The remaining patient developed an optic nerve GS after suffering a bone marrow relapse. All three patients received irradia tion for the GS and systemic chemotherapy before the allo-BMT, TBI was used for conditioning, and GVHD prophylaxis was with cyclosporine (CsA) and sho rt-term MTX in all three cases. These patients are currently 9 to 37 months post-BMT without relapse. Thus, our experience suggests that allo-BMT is a n effective treatment for AML patients with existing or pre-existing intrac erebral GS.