Allogeneic bone marrow transplantation for advanced Waldenstrom's macroglobulinemia

Waldenstrom's disease is a lymphoproliferative disorder that is typically t reated with plasmapheresis and/or alkylating agents. In young patients, oth er lymphoproliferative disorders have been treated with allogeneic transpla ntation. Two patients with aggressive Waldenstrom's disease, who progressed in spite of multi-agent chemotherapy and autologous stem cell transplantat ion, in one case, underwent allogeneic transplantation from their HLA-ident ical donors. Both remain alive with event-free survivals of more than 3, an d more than 9 years, respectively. Allogeneic transplantation should be con sidered for young patients with Waldenstrom's disease.