Paralytic poliomyelitis associated with live oral poliomyelitis vaccine inchild with HIV infection in Zimbabwe: case report

Objective To describe a complication of oral vaccination with live, attenua ted poliomyelitis virus in a child infected with HIV. Design Case report. Setting Teaching hospital in Harare, Zimbabwe. Subjects A boy of 41/2 years and his mother. Main outcome measures. Results of clinical and laboratory investigations. Results Two weeks after receiving the second dose of oral poliomyelitis vac cine during national immunisation days the child developed paralysis of the right leg. He had a high titre of antibodies against poliovirus type 2, as well as antibodies against HIV-1, a low CD4 count, a ratio of CD4 to CD8 c ount of 0.47, and hypergammaglobulinaemia. He did not have any antibodies a gainst diphtheria, tetanus, or poliovirus types 1 and 3, although he had be en given diphtheria, tetanus, and pertussis and oral polio vaccines during his first year and a booster of the diphtheria, tetanus, and pertussis vacc ine at 24 months. He had no clinical symptoms of AIDS, but his mother had A IDS and tuberculosis. Conclusion Paralytic poliomyelitis in this child with HIV infection was cau sed by poliovirus type 2 after oral poliomyelitis vaccine.