The total synthesis of a technetium chelate-tamoxifen complex

Authors
Bell, RA Dickson, KC Valliant, JF
Citation
Ra. Bell et al., The total synthesis of a technetium chelate-tamoxifen complex, CAN J CHEM, 77(1), 1999, pp. 146-154
Citations number
21
Categorie Soggetti
Chemistry
Journal title
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
ISSN journal
00084042 → ACNP
Volume
77
Issue
1
Year of publication
1999
Pages
146 - 154
Database
ISI
SICI code
0008-4042(199901)77:1<146:TTSOAT>2.0.ZU;2-V
Abstract
A potential agent for imaging breast cancer has been synthesized by derivat ization of the anti-estrogen tamoxifen. A multistep synthesis was required to conjugate a technetium chelate to tamoxifen in such a fashion that the b iodistribution of the complex should mimic that of the parent compound.