New chemoenzymatic approach to glyco-lipopolymers: practical preparation of functionally active galactose-poly(ethyleneglycol)-distearoylphosphatidicacid (Gal-PEG-DSPA) conjugate

Authors
Zalipsky, S Mullah, N Dibble, A Flaherty, T
Citation
S. Zalipsky et al., New chemoenzymatic approach to glyco-lipopolymers: practical preparation of functionally active galactose-poly(ethyleneglycol)-distearoylphosphatidicacid (Gal-PEG-DSPA) conjugate, CHEM COMMUN, (7), 1999, pp. 653-654
Citations number
14
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
7
Year of publication
1999
Pages
653 - 654
Database
ISI
SICI code
1359-7345(19990407):7<653:NCATGP>2.0.ZU;2-E
Abstract
A practical approach to galactose-PEG-distearoylphosphatidic acid (DSPA) re taining full lectin binding, involves glycosylation of monobenzyl ether-PEG , suitable protection of the sugar hydroxy groups, debenzylation, followed by enzymatic transphosphatidylation with phosphatidylcholine and final depr otection.