The growth of several micro-organism and the formation of primary metabolit
es are impaired by the high concentrations of the products. Their removal d
uring the cultivation is desirable. This can be realised by different metho
ds. Reactive-Membrane-Extraction could be useful if not ethanol but the est
er is the desired product. Ethanol should be extracted from the aqueous pha
se into an octane phase in a hollow fiber module and converted in to the ph
ase with caprylic (octanoic) acid in ethylcaproate.