An artificial signal transduction system. Control of lactate dehydrogenaseactivity performed by an artificial cell-surface receptor

A supramolecular bilayer assembly as an artificial signaling system was con stituted in combination with a steroid cyclophane as an artificial receptor , an NADH-dependent lactate dehydrogenase as an effector, and a bilayer-for ming peptide lipid. Signal transduction from the receptor to the effector w as observed for the present hybrid system by employing two kinds of signali ng spec ies, 1-hydroxy-2-naphthaldehyde as an external signal and a Cu(IT) ion as a signal transmitter.