Chiral 1,2-bis(phosphetano)benzenes: Preparation and use in the Ru-catalyzed hydrogenations of carbonyl derivatives

Authors
Marinetti, A Genet, JP Jus, S Blanc, D Ratovelomanana-Vidal, V
Citation
A. Marinetti et al., Chiral 1,2-bis(phosphetano)benzenes: Preparation and use in the Ru-catalyzed hydrogenations of carbonyl derivatives, CHEM-EUR J, 5(4), 1999, pp. 1160-1165
Citations number
31
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY-A EUROPEAN JOURNAL
ISSN journal
09476539 → ACNP
Volume
5
Issue
4
Year of publication
1999
Pages
1160 - 1165
Database
ISI
SICI code
0947-6539(199904)5:4<1160:C1PAUI>2.0.ZU;2-M
Abstract
Chiral 1,2-bis(phosphetano)benzenes are readily prepared from accessible, o ptically pure 1,3-diol cyclic sulfates. Their ruthenium complexes catalyze the enantioselective hydrogenations of functionalized carbonyls with modera te-to-high enantiomeric excesses. High levels of diastereo- and enantiosele ctivity are achieved, especially in the hydrogenation of beta-diketones to the corresponding anti-1,3-diols.