Tc. Schmidt et al., Synthesis of reference substances for highly polar metabolites of nitroaromatic compounds, CHEMOSPHERE, 38(13), 1999, pp. 3119-3130
Transformation processes of nitroaromatic compounds (NAC) lead to polar and
highly hydrophilic metabolites. For the unequivocal identification of prop
osed metabolites reference substances are needed. Since most of them are no
t commercially available, their synthesis was done in our group. In many ca
ses no satisfying synthesis schemes were found in the literature. In this c
ommunication, we therefore describe the preparation, structural elucidation
and separation of 17 compounds. Many of the newly synthesized analytes wer
e found in various water samples from a former ammunition plant, (C) 1999 E
lsevier Science Ltd. All rights reserved.