Level, sources and toxicity of polychlorinated biphenyls in the Italian diet

We used the duplicate portion method to measure the daily dietary intake of total and congener-specific polychlorinated biphenyls (PCB) and to assess their potential toxicity in a group of 20 subjects consuming a typical Ital ian diet. The mean+/-SD intake of total PCB, measured by GC-MS, was 3.72+/-1.51 mu g/ person/day, comparable to values reported in similar studies world-wide, wi th individual intakes varying within one order of magnitude, from 0.97 to 1 0.59 mu g/person/day. The di-ortho congeners 153, 18 and 138 were the PCB f ound in the highest concentrations (respectively 13.8%, 11.4% and 10.9% of the total) while the non-ortho coplanar congeners (77, 126 and 169) amounte d to 0.5% of the total. The corresponding levels of toxicity (TCDD-like TEQ values ascribable to PC B) ranged from 4.6 up to 119 pg/person/day of TCDD-equivalents in 18 subjec ts, i.e. presumed no-risk levels, but with peaks of 2109 and 4553 pg/person /day in two subjects with significant intakes of the congener 126. wprincipal components analysis and redundancy analysis showed dairy product s, meat and fish were the principal sources of PCB, and vegetables those wi th the highest toxicity index in the Italian diet. (C) 1999 Elsevier Scienc e Ltd. All rights reserved.