Biosensors in biomedical research: Development and applications of gene chips

Citation
U. Certa et al., Biosensors in biomedical research: Development and applications of gene chips, CHIMIA, 53(3), 1999, pp. 57-61
Citations number
6
Categorie Soggetti
Chemistry
Journal title
CHIMIA
ISSN journal
00094293 → ACNP
Volume
53
Issue
3
Year of publication
1999
Pages
57 - 61
Database
ISI
SICI code
0009-4293(1999)53:3<57:BIBRDA>2.0.ZU;2-T
Abstract
Nucleic-acid hybridisation techniques are a central tool for the genetic an alysis of biological systems. Gene chips are complex arrays of recombinant plasmids or oligonucleotides immobilised on a glass chip of only 1 cm(2). T his technology allows, for the first time, the multiparallel expression-ana lysis of thousands of genes. Gene chips will be indispensable tools for the upcoming analysis of the human genome, once the entire sequence is known.