Combined factor V and factor VII deficiency due to an independent segregation of the two defects

A patient with combined factor V and factor VII deficiency is described tog ether with a family study. The propositus appeared to be double heterozygou s for factor V and factor VII deficiency. Since the patient showed a parall el decrease of activity and antigen, he appeared to be double heterozygous for a true deficiency. The patient had inherited the factor V defect from t he mother and the factor VII defect from the father. The parents of the pro positus were not consanguineous. Other family members were found to have is olated factor V or factor VII deficiency. This is the third family so far d escribed with this peculiar combined defect but the first to be investigate d by clotting and immunologic assays.