The occurrence of Poland and Poland-Moebius syndromes in the same family: further evidence of their genetic component

The combination of Moebius and Poland anomalies is rarely described in the literature. Some authors believe that this association is an independent sy ndrome, while others propose that Poland, Moebius and Poland-Moebius are a spectrum of the same condition. Here we report a family where a child has P oland-Moebius syndrome and an aunt is affected with Poland anomaly. This pr obably represents the second report of possible autosomal dominant transmis sion of Poland-Moebius syndrome. The presence of contralateral triphalangea l thumb in the proband and in other members of the family can be explained by chance alone or, alternatively, by a pleiotropic expression of this gene . Clin Dysmorphol 8: 93-99 (C) 1999 Lippincott Williams & Wilkins.