Fe-S proteins in sensing and regulatory functions

Authors
Beinert, H Kiley, PJ
Citation
H. Beinert et Pj. Kiley, Fe-S proteins in sensing and regulatory functions, CURR OP C B, 3(2), 1999, pp. 152-157
Citations number
59
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
3
Issue
2
Year of publication
1999
Pages
152 - 157
Database
ISI
SICI code
1367-5931(199904)3:2<152:FPISAR>2.0.ZU;2-A
Abstract
In the past five to ten years, it has become increasingly apparent that the function of Fe-S clusters is not limited to electron transfer, a function implicit in their discovery. We now know that the vulnerability of these st ructures to oxidative destruction is used by nature in sensing O-2, iron, a nd possibly also nitric oxide. Changes in the oxidation state of Fe-S clust ers can also serve as a reversible switch.