Histone acetylation and cancer

Authors
Archer, SY Hodin, RA
Citation
Sy. Archer et Ra. Hodin, Histone acetylation and cancer, CUR OP GEN, 9(2), 1999, pp. 171-174
Citations number
32
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
9
Issue
2
Year of publication
1999
Pages
171 - 174
Database
ISI
SICI code
0959-437X(199904)9:2<171:HAAC>2.0.ZU;2-W
Abstract
In the past year, several papers have been published which implicate a link between alterations in chromatin structure and the development of cancer. Both histone hyperacetylation and hypoacetylation appear to be important in the neoplastic process, depending on the target gene involved, In the case of colon cancer, induction of the p21 gene by histone hyperacetylation may be a mechanism by which dietary fiber prevents carcinogenesis.