C. Pretti et al., Effect of clofibrate, a peroxisome proliferator, in sea bass (Dicentrarchus labrax), a marine fish, ENVIR RES, 80(3), 1999, pp. 294-296
The effects of 35 or 70 mg/kg clofibrate on some peroxisomal, mitochondrial
, and microsomal enzymes (markers of peroxisome proliferation) in liver, gi
ll, and kidney of sea bass following 2 weeks i.p. treatment have been studi
ed, Induction of lauric acid hydroxylase, UDP-glucuronyl transferase, palmi
toyl-CoA oxidase, carnitine-palmitoyl-transferase, p-nitrophenylacetate hyd
rolase, and benzaldehyde and propionaldehyde dehydrogenase activities was n
ot observed in any case. The clofibrate administration at the dose of 70 mg
/kg induced in the liver the glutathione S-tranferase and reduced epoxide h
ydrolase activities. These results demonstrate that a marine fish species,
such as sea bass, is rafractary to peroxisome proliferation. (C) 1999 Acade
mic Press.