Effect of clofibrate, a peroxisome proliferator, in sea bass (Dicentrarchus labrax), a marine fish

Citation
C. Pretti et al., Effect of clofibrate, a peroxisome proliferator, in sea bass (Dicentrarchus labrax), a marine fish, ENVIR RES, 80(3), 1999, pp. 294-296
Citations number
21
Categorie Soggetti
Environment/Ecology,"Pharmacology & Toxicology
Journal title
ENVIRONMENTAL RESEARCH
ISSN journal
00139351 → ACNP
Volume
80
Issue
3
Year of publication
1999
Pages
294 - 296
Database
ISI
SICI code
0013-9351(199904)80:3<294:EOCAPP>2.0.ZU;2-F
Abstract
The effects of 35 or 70 mg/kg clofibrate on some peroxisomal, mitochondrial , and microsomal enzymes (markers of peroxisome proliferation) in liver, gi ll, and kidney of sea bass following 2 weeks i.p. treatment have been studi ed, Induction of lauric acid hydroxylase, UDP-glucuronyl transferase, palmi toyl-CoA oxidase, carnitine-palmitoyl-transferase, p-nitrophenylacetate hyd rolase, and benzaldehyde and propionaldehyde dehydrogenase activities was n ot observed in any case. The clofibrate administration at the dose of 70 mg /kg induced in the liver the glutathione S-tranferase and reduced epoxide h ydrolase activities. These results demonstrate that a marine fish species, such as sea bass, is rafractary to peroxisome proliferation. (C) 1999 Acade mic Press.