Effect of clofibrate, a peroxisome proliferator, in sea bass (Dicentrarchus labrax), a marine fish

The effects of 35 or 70 mg/kg clofibrate on some peroxisomal, mitochondrial , and microsomal enzymes (markers of peroxisome proliferation) in liver, gi ll, and kidney of sea bass following 2 weeks i.p. treatment have been studi ed, Induction of lauric acid hydroxylase, UDP-glucuronyl transferase, palmi toyl-CoA oxidase, carnitine-palmitoyl-transferase, p-nitrophenylacetate hyd rolase, and benzaldehyde and propionaldehyde dehydrogenase activities was n ot observed in any case. The clofibrate administration at the dose of 70 mg /kg induced in the liver the glutathione S-tranferase and reduced epoxide h ydrolase activities. These results demonstrate that a marine fish species, such as sea bass, is rafractary to peroxisome proliferation. (C) 1999 Acade mic Press.