A. Van Der Meijden et al., Significance of bladder biopsies in Ta,T1 bladder tumors: A report from the EORTC Genito-Urinary Tract Cancer Cooperative Group, EUR UROL, 35(4), 1999, pp. 267-271
Objectives: We investigated to what extent biopsies of normal-appearing uro
thelium taken from patients with Ta,T1 bladder cancer showed malignant dise
ase: carcinoma in situ, or papillary tumor. We also investigated biopsies u
nderlying the papillary tumor, adjacent to the tumor, and from suspicious-a
ppearing mucosa. Methods: In EORTC protocol 30863 (low-risk tumors), 393 pa
tients underwent a biopsy of normal-appearing urothelium. In protocol 30911
(intermediate- and high-risk tumors), multiple biopsies were taken from no
rmal-appearing urothelium in 602 patients. Results: No abnormalities were f
ound in the random biopsies of 376 (95.6%) patients with low-risk tumors an
d in 532 (88.4%) patients with intermediate- and high-risk tumors. Six (1.5
%) patients with low-risk tumors and at least 21 (3.5%) patients with highe
r-risk tumors showed carcinoma in situ in their random biopsies. None of th
e patients in the low-risk group and 1 (0.2%) patient in higher-risk group
had an invasive tumor (greater than or equal to T2). Conclusions: This anal
ysis indicates that biopsies of normal-appearing urothelium in Ta,T1 bladde
r cancer patients show no abnormalities in about 90% of the patients. Perfo
rming such biopsies does not contribute to the staging or to the choice of
adjuvant therapy after transurethral resection.