Regulation of bile acid biosynthesis

Authors
Vlahcevic, ZR Pandak, WM Stravitz, RT
Citation
Zr. Vlahcevic et al., Regulation of bile acid biosynthesis, GASTRO CLIN, 28(1), 1999, pp. 1
Citations number
140
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
ISSN journal
08898553 → ACNP
Volume
28
Issue
1
Year of publication
1999
Database
ISI
SICI code
0889-8553(199903)28:1<1:ROBAB>2.0.ZU;2-F
Abstract
This article provides a review of the pathways through which cholesterol is degraded to bile acids. Regulation of key enzymes in the bile acid biosynt hestic pathways is discussed. The important role of these pathways in the m aintenance of cholesterol homeostasis and the possible therapeutic implicat ions for the treatment of hypercholesterolemia are emphasized.