Method for constructing confidently ordered linkage maps

Authors
Broman, KW Weber, JL
Citation
Kw. Broman et Jl. Weber, Method for constructing confidently ordered linkage maps, GENET EPID, 16(4), 1999, pp. 337-343
Citations number
7
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
16
Issue
4
Year of publication
1999
Pages
337 - 343
Database
ISI
SICI code
0741-0395(1999)16:4<337:MFCCOL>2.0.ZU;2-0
Abstract
We describe a method for identifying, from a comprehensive genetic map, the most dense framework of confidently ordered markers. The approach uses the number of observed recombination events between each pair of markers, and finds the largest subset of markers for which adjacent loci are separated b y at least one recombination. We illustrate the approach using a short regi on of chromosome 7p. Genet. Epidemiol. 16:337-343, 1999. (C) 1999 Wiley-Lis s, Inc.