Pathogenesis of endometriosis: The role of peritoneal fluid

Peritoneal fluid is a specific microenvironment. It originates mainly as an ovarian exudation product due to increased vascular permeability, and cont ains large amounts of macrophages and their secretion products, which inclu de growth factors, cytokines and angiogenic factors. Similarly, within the ovary, there is also a specific microenvironment, best characterised by the follicular milieu with steroid hormone concentrations that are 1,000 times higher than in plasma. Since endometrial cells in peritoneal fluid and sup erficially implanted cells will be influenced by peritoneal fluid concentra tions, any differences found between minimal endometriosis and eutopic endo metrium could be the consequence of their different local environments, rat her than inherent cellular differences. Superficial endometrial implants ma y be regulated by factors in peritoneal fluid, while deep endometriosis and cystic ovarian endometriosis may be under the influence of factors in bloo d and within the ovary, in which case minimal endometriosis may be physiolo gic only, while deep endometriosis and cystic ovarian endometriosis, both a ssociated with pelvic pain and infertility, may be a pathological state. In conclusion, the local endocrine environment, that is, in blood, peritoneal fluid, and within the ovary, should be taken into account to explain the d ifferences between superficial, deep and cystic ovarian endometriosis, toge ther with inherent differences in the endometrial cells of women with and w ithout endometriosis.