In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study

A total of 3903 pathogens from 48 Canadian medical centres were tested agai nst 19 antimicrobial agents. Five agents showed activity against, greater t han or equal to 90% of all 1982 respiratory tract pathogens tested (ciprofl oxacin, 90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime a nd imipenem, 93% each). Nine agents had,90% activity against Enterobacteria ceae from respiratory tract infection (cefotaxime and ticarcillin/clavulana te, 90% each; aztreonam, ceftizoxime and ceftriaxone, 91% each; ceftazidime , 93%; ciprofloxacin, 97%; imipenem and netilmicin, 98% each). Similarly, f ive agents had activity against,90% of all 1921 urinary tract pathogens tes ted (ciprofloxacin and ticarcillin/clavulanate, 90% each; cefoperazone and netilmicin, 91% each; imipenem, 99%). Nine agents had greater than or equal to 95% activity against Enterobacteriaceae from urinary tract infection (c iprofloxacin, 95%; cefotetan, 97%; aztreonam, cefotaxime, ceftazidime, ceft izoxime, ceftriaxone and netilmicin, 98% each; imipenem, 99%). Seventeen ag ents had activity against, 95% of Staphylococcus aureus strains. Susceptibi lity of Pseudomonas aeruginosa isolates ranged from 2% to 91%.