beta-blocker effects on plasma lipids during prolonged treatment of hypertensive patients with hypercholesterolemia

The aim of this study was to compare the effects of long-term monotherapy w ith four different beta-blockers on plasma lipids in hypercholesterolemic h ypertensive patients. We studied 152 subjects with essential hypertension [ diastolic blood pressure (DBP) >90 mm Hg], total cholesterol (TC) >240 and <330 mg/dl, and triglycerides (TGs) <300 mg/dl. After a ii-week washout per iod with placebo, patients were randomized to receive propranolol, 160 mg/d ay (n = 37), atenolol, 100 mg/day (n = 38). bisoprolol, 10 mg/day (n = 39), or celiprolol, 400 mg/day (n = 38), for 18 months. No cholesterol-reducing drug was allowed. Blood samples for evaluation of TC. low-density lipoprot ein cholesterol (LDL-C), HDL cholesterol (HDL-C), and TGs were taken before and after the placebo period and subsequently every 6 months. No beta-bloc ker worsened TC or LBL-C. Nonselective propranolol caused the most pronounc ed changes ill HDL-C and TGs. beta(1)-Selective atenolol produced the same qualitative effects, but to a lesser extent. The more beta(1)-selective bis oprolol did not affect HDL-C and TGs. Celiprolol significantly improved the lipid profile by significantly decreasing TC, LDL-C, and TGs, and increasi ng HDL-C. These findings suggest that in hypercholesterolemic hypertensive patients, (a) beta(1)-selective beta-blockers are likely to adversely affec t plasma lipids to a lesser extent than nonselective ones; and (b) celiprol ol is able to improve the lipid pattern, which could be because of its pecu liar ancillary properties.