The Alexander Project is a continuing, international, multicenter, longitud
inal study of the antimicrobial susceptibility of pathogens commonly associ
ated with community-acquired lower respiratory tract infections (LRTI), The
study began in 1992 to provide high-quality surveillance data, comparable
between regions and through time. As antimicrobial resistance becomes more
prevalent, reliable surveillance data are required for clinical decision-ma
king. Accurate current susceptibility data are required to predict clinical
success through the determination of pharmacodynamic breakpoints. The Alex
ander Project provides the information required for clinicians to improve t
he likelihood of microbiological and clinical cure in the antibiotic treatm
ent of LRTI.