Synthesis of 3 beta-(4-[I-125]Iodophenyl)tropane-2 beta-pyrrolidine carboxamide ([I-125]RTI-229)

Authors
Zhong, DS Kotian, P Wyrick, CD Seltzman, HH Kepler, JA Boja, JW Kuhar, MJ Carroll, FI
Citation
Ds. Zhong et al., Synthesis of 3 beta-(4-[I-125]Iodophenyl)tropane-2 beta-pyrrolidine carboxamide ([I-125]RTI-229), J LABEL C R, 42(3), 1999, pp. 281-286
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
42
Issue
3
Year of publication
1999
Pages
281 - 286
Database
ISI
SICI code
0362-4803(199903)42:3<281:SO3BBC>2.0.ZU;2-H
Abstract
A WIN 35,055-2 analog, 3 beta-(4-iodophenyl)tropane-2 beta-pyrrolidine carb oxamide (RTI-229), has been radiolabelled with iodine-125 by radioiododesta nnylation of the corresponding trimethyltin derivative using carrier-free s odium iodide-125 as the isotope source. Purification by reversed-phase HPLC gives [I-125]RTI-229 in good yield (89.4%) with high radiochemical purity (>99%) and high specific activity (2125 mCi/mu mol, 78.6 GBq/mu mol, based on the specific activity of the (NaI)-I-125 used).