Preparation of Au-198(I)-labelled gold-chloroquine complex [Au-198(PPh3)(CQ)]PF6 as a potential antimalarial agent

Authors
Dadachova, E
Citation
E. Dadachova, Preparation of Au-198(I)-labelled gold-chloroquine complex [Au-198(PPh3)(CQ)]PF6 as a potential antimalarial agent, J LABEL C R, 42(3), 1999, pp. 287-292
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
42
Issue
3
Year of publication
1999
Pages
287 - 292
Database
ISI
SICI code
0362-4803(199903)42:3<287:POAGC[>2.0.ZU;2-R
Abstract
Au-198(I)-labelled gold-chloroquine complex [Au-198(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-res istant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)] PF6. [Au-198(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with i rradiated in the reactor for 2 hours Au foil and purified on Sep-Pak(R) C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibilit y of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.