DESFERRIOXAMINE TREATMENT REDUCES HISTOLOGICAL EVIDENCE OF LUNG DAMAGE IN RATS AFTER ACUTE NITROGEN-DIOXIDE (NO2) INTOXICATION

Authors
MEULENBELT J DORMANS JAMA VANBREE L ROMBOUT PJA SANGSTER B
Citation
J. Meulenbelt et al., DESFERRIOXAMINE TREATMENT REDUCES HISTOLOGICAL EVIDENCE OF LUNG DAMAGE IN RATS AFTER ACUTE NITROGEN-DIOXIDE (NO2) INTOXICATION, Human & experimental toxicology, 12(5), 1993, pp. 389-395
Citations number
20
Categorie Soggetti
Toxicology
Journal title
Human & experimental toxicology → ACNP
ISSN journal
09603271
Volume
12
Issue
5
Year of publication
1993
Pages
389 - 395
Database
ISI
SICI code
0960-3271(1993)12:5<389:DTRHEO>2.0.ZU;2-D
Abstract
1 In previous studies a rat inhalation model was developed to investig ate the efficacy of treatment in acute NO2 intoxication. 2 Desferrioxa mine was administered intravenously to study its effect on histologica l alterations in lung tissue in rats after acute NO2 exposure. 3 Twent y four hours after exposure to 175 ppm NO2 for 10 minutes the lung inj ury observed by light microscopy in the desferrioxamine treated rats w as less pronounced than in the saline treated rats. 4 Desferrioxamine appeared to provide more protection with a dose of 1 00 mg kg-1 24 h-1 than with 200 mg kg-1 24 h-1.