In vitro and in vivo toxicity of magnetic microspheres

Authors
Hafeli, UO Pauer, GJ
Citation
Uo. Hafeli et Gj. Pauer, In vitro and in vivo toxicity of magnetic microspheres, J MAGN MAGN, 194(1-3), 1999, pp. 76-82
Citations number
21
Categorie Soggetti
Apllied Physucs/Condensed Matter/Materiales Science
Journal title
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
ISSN journal
03048853 → ACNP
Volume
194
Issue
1-3
Year of publication
1999
Pages
76 - 82
Database
ISI
SICI code
0304-8853(199904)194:1-3<76:IVAIVT>2.0.ZU;2-3
Abstract
The interaction of magnetic microspheres with cells was studied using an in vitro 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (= MTT) assay. Viability and metabolic activity were reduced in all examples. The M TT assay is not recommended for this application due to high variability an d non-specificity. Poly(lactic acid) microspheres were further tested in vi vo. Intrathecal injection in rats produced no obvious side effects: over 12 months. (C) 1999 Elsevier Science B.V. All rights reserved.