Physiological aspects in magnetic drug-targeting

Citation
As. Lubbe et al., Physiological aspects in magnetic drug-targeting, J MAGN MAGN, 194(1-3), 1999, pp. 149-155
Citations number
8
Categorie Soggetti
Apllied Physucs/Condensed Matter/Materiales Science
Journal title
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
ISSN journal
03048853 → ACNP
Volume
194
Issue
1-3
Year of publication
1999
Pages
149 - 155
Database
ISI
SICI code
0304-8853(199904)194:1-3<149:PAIMD>2.0.ZU;2-D
Abstract
The efficacy of magnetically-controlled drug targeting (MDT) depends on phy siological parameters. To understand its mechanism of action on the tissue at the microcirculatory level, we identified the ferrofluids potential (its biological effects, its bioavailability and the in vivo desorption time of the anticancer drug epirubicin). Mechanical tumor embolization was possibl e, but successful tumor treatment was sometimes bypassed by a developing co llateral circulation. Thus, MDT-treatment was used successfully in mice and in man. (C) 1999 Elsevier Science B.V. All rights reserved.