We have developed 'magnetite cationic liposomes' (MCLs) as a new heating me
diator for hyperthermia. The hyperthermic effect on solid glioma tissue gro
wn subcutaneously in F344 rats was investigated. Complete tumor regression
was observed in about 90% of the rats by three times of repeated heating. F
urthermore, induction of antitumor immunity for T-9 rat glioma using MCLs w
as investigated. (C) 1999 Elsevier Science B.V. All rights reserved.