Y. Maruo et al., The effect of diabetes mellitus on histopathological changes in the tissues under denture base bearing masticatory pressure, J ORAL REH, 26(4), 1999, pp. 345-355
The effect of streptozotocin-induced diabetes mellitus on histopathological
changes in tissues bearing masticatory pressure exerted through an experim
ental denture base has been studied in animal specimens. Experimental dentu
res, which prescribed the masticatory pressure by the amount of subsidence
of the denture base (100, 50 or 13 mu m), were constructed for the hard pal
ate of the molar regions of rats. It was revealed that streptozotocin-induc
ed diabetes mellitus (1) weakened the intercellular junctions in the epithe
lium and gradually enhanced this state with time, (2) lessened the atrophic
and proliferative reactions in the epithelial ridge and prolonged their ap
pearance period, (3) enhanced the compression of lamina propria mucosae and
prolonged the appearance period of this reaction, (4) enhanced the inflamm
atory change and extended its appearance period, (5) lowered the threshold
for the inflammatory reaction induces by the masticatory pressure, (6) incr
eased the number of osteoclasts and prolonged the period of their presence,
(7) lowered the threshold for osteoclastic bone resorption induced by the
masticatory pressure, (8) inhibited the appearance of osteoblasts following
the disappearance of osteoclasts and (9) accelerated the decline rate of m
asticatory pressure exerted to the denture supporting tissues. Therefore, i
t can be concluded that the streptozotocin-induced diabetes mellitus in the
animals tested deteriorated the tolerance of the denture supporting tissue
s to masticatory pressure.