Hypoadrenocorticism as the primary manifestation of lymphoma in two cats

Hypoadrenocorticism secondary to bilateral lymphomatous invasion of adreno cortical tissue was diagnosed in 2 adult castrated domestic shorthair cats. In both cats, findings during initial physical examination (ie, lethargy, anorexia, weight loss, and severe weakness) were consistent with severe hyp oadrenocorticism. Hyperkalemia, hyponatremia, and azotemia were also detect ed, which were consistent with hypoadrenocorticism. Hypoadrenocorticism was documented on the basis of finding low baseline and ACTH-stimulated serum cortisol concentrations. The cats initially responded well to treatment, bu t both owners chose to have the cat euthanatized. Multicentric lymphoma wit h infiltration and destruction of the adrenal glands was confirmed during n ecropsy.