Hyperplasia of sebacceous glands (Fordyce's disease) in an oral mucocutaneous graft: Follow-up over 45 years

Background Diffuse sebaceous gland hyperplasia in transplanted buccal mucos a is a very rare condition. We report on a further patient with this entity . Patient In 1953, a now 68-year-old man suffered a severe alkali burn. Trans plantation of oral mucosa was performed that same day in order to prevent p erforation of the eye. Over the following 45 years, the patient developed m ultiple yellowish nodules within the grafts. Histologically, these nodules proved to be normally differentiated sebaceous glands. Conclusions Diffuse sebaceous gland hyperplasia originating from within ora l mucosa and developing over an extended period of time is a clinical entit y known as Fordyce's disease. It is this a late complication of mucocutaneo us transplantation, and although it constitutes mainly a problem of cosmesi s, functionally it can lead to aberrant secretion of sebum.