As a form of matter intermediate between molecules and bulk solids, atomic
clusters have been much studied(1). Light-induced processes in dusters can
lead to photo-fragmentation(2,3) and Coulombic fission(4), producing atom a
nd ion fragments with a few electron volts (eV) of energy. However, recent
studies of the photoionization of atomic dusters with high intensity (>10(1
6)Wcm(-2)) femtosecond laser pulses have shown that these interactions can
be far more energetid(5-13)-excitation of large atomic dusters can produce
a superheated microplasma that ejects ions with kinetic energies up to 1 Me
V (ref. 10). This phenomenon suggests that through irradiation of deuterium
dusters, it would be possible to create plasmas with sufficient average io
n energy for substantial nuclear fusion. Here we report the observation of
nuclear fusion from the explosions of deuterium clusters heated with a comp
act, high-repetition-rate table-top laser. We achieve an efficiency of abou
t 10(5) fusion neutrons per joule of incident laser energy, which approache
s the efficiency of large-scale laser-driven fusion experiments. Our result
s should facilitate a range of fusion experiments using: small-scale lasers
, and may ultimately lead to the development of a table-top neutron source,
which could potentially find wide application in materials studies.