T. Sawa et al., Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury, NAT MED, 5(4), 1999, pp. 392-398
Citations number
40
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can caus
e fatal acute lung infections in critically ill individuals. Damage to the
lung epithelium is associated with the expression of toxins that are direct
ly injected into eukaryotic cells through a type Ill-mediated secretion and
translocation mechanism. Here we show that the P. aeruginosa homolog of th
e Yersinia V antigen, PcrV, is involved in the translocation of type III to
xins. Vaccination against PcrV ensured the survival of challenged mice and
decreased lung inflammation and injury. Antibodies to PcrV inhibited the tr
anslocation of type III toxins.