Recent major surgery is an exclusion criterion for thrombolysis. Six patien
ts with acute ischemic stroke underwent intra-arterial thrombolysis after r
ecent open heart surgery without clinically significant bleeding complicati
ons, although one patient developed a small, asymptomatic cerebellar hemorr
hage. Intra-arterial thrombolysis may be an option for patients with cerebr
al embolism in the perioperative period.