Expression of protective protein in human tissue

The authors investigated by immunohistochemistry the distribution of protec tive protein in human tissues. Immunoreactivity was observed in the cytopla sm, revealing a granular pattern and cell type specificity. The most intens e staining was observed in the large neurons of brain, distal and collectin g tubular cells of kidney, epithelial cells of bronchus, and Leydig cells o f testis, In a patient with galactosialidosis type IIa, all these stains we re absent. The neurons that were most strongly stained in the control group , such as the Betz cells, neurons in the basal forebrain, motor neurons in the cranial nerve nuclei, and ventral horn cells of the spinal cord, were m arkedly ballooned in the patient with galactosialidosis, (C) 1999 by Elsevi er Science Inc. All rights reserved.