A survey of post-discharge side effects of conscious sedation using chloral hydrate in pediatric CT and MR imaging

Background. Limited information is available on post-discharge side effects of chloral hydrate sedation in pediatric imaging. Objective. To prospectively study the post-discharge side effects of chlora l hydrate sedation in pediatric CT and MR imaging. Materials and methods. A total of 119 children undergoing CT and MRI were s edated using chloral hydrate with 89 % success (mean initial dose, 72 mg/kg body weight) and 98 % success after augmentation (mean total, 78 mg/kg bod y weight). The frequency of each post-discharge side effect was correlated with other side effects and 12 patient/technical parameters. Results. The survey was completed in 80 children. Sleepiness lasted for > 4 h in 28 %. Unsteadiness occurred in 68 % and hyperactivity in 29 %. Appeti te became poor in 14 % and vomiting occurred in 15 %. Normal activity was r esumed after > 4 h in 54 %. Sleep deprivation did not result in increased s uccess or earlier onset of sedation and might be associated with hyperactiv ity. A higher dose did not result in an increased success rate or earlier o nset of sedation within the dose range used in this study. Conclusion. Data on the post-discharge side effects of chloral hydrate seda tion will be useful to radiologists, technologists, and nurses explaining t o parents about sedation using this agent.