A review of eprosartan pharmacokinetic and pharmacodynamic drug interaction studies

A series of clinical pharmacology studies was conducted to characterize pot ential interactions between eprosartan and other commonly prescribed drugs. Separate studies assessed the effect of eprosartan on the pharmacokinetics of digoxin and hydrochlorothiazide (HCTZ) and the pharmacodynamics of warf arin and glyburide (glibenclamide), as well as the effects of ranitidine, H CTZ, fluconazole, and ketoconazole on eprosartan pharmacokinetics. Eprosart an had no significant effect on the pharmacokinetics of digoxin and HCTZ an d the pharmacodynamics of warfarin and glyburide. Thus, no dosing adjustmen ts are necessary during concomitant therapy with these agents. Ranitidine, HCTZ, ketoconazole, and fluconazole had no effect on eprosartan pharmacokin etics. Single or multiple oral doses of eprosartan were safe and well toler ated when coadministered with these agents.