Safety and tolerability of eprosartan

Citation
I. Gavras et H. Gavras, Safety and tolerability of eprosartan, PHARMACOTHE, 19(4), 1999, pp. 102S-107S
Citations number
27
Categorie Soggetti
Pharmacology
Journal title
PHARMACOTHERAPY
ISSN journal
02770008 → ACNP
Volume
19
Issue
4
Year of publication
1999
Part
2
Supplement
S
Pages
102S - 107S
Database
ISI
SICI code
0277-0008(199904)19:4<102S:SATOE>2.0.ZU;2-2
Abstract
The safety and tolerability of eprosartan were extensively assessed in 17 p hase IIb-III studies that included 2709 patients with hypertension. The fre quency of adverse events observed with eprosartan was similar to that seen with placebo. Neither the number nor the severity of these effects increase d with prolonged therapy, and their frequency was not affected by increased eprosartan dosage or dosing frequency. The drug is equally well tolerated by women and men, by younger (< 65 yrs) and older (greater than or equal to 65 yrs) individuals, and by persons of all races. There are no known drug interactions, and eprosartan is well tolerated when given in combination wi th other frequently prescribed antihypertensive agents, without an increase in adverse events beyond those expected of baseline antihypertensive thera py.