The safety and tolerability of eprosartan were extensively assessed in 17 p
hase IIb-III studies that included 2709 patients with hypertension. The fre
quency of adverse events observed with eprosartan was similar to that seen
with placebo. Neither the number nor the severity of these effects increase
d with prolonged therapy, and their frequency was not affected by increased
eprosartan dosage or dosing frequency. The drug is equally well tolerated
by women and men, by younger (< 65 yrs) and older (greater than or equal to
65 yrs) individuals, and by persons of all races. There are no known drug
interactions, and eprosartan is well tolerated when given in combination wi
th other frequently prescribed antihypertensive agents, without an increase
in adverse events beyond those expected of baseline antihypertensive thera
py.