Protein S-100B and neuron specific enolase as early neurobiochemical markers of the severity of traumatic brain injury

The present study aimed at the predictive value of early release patterns o f protein S-100B and neuron specific enolase (NSE) in patients with traumat ic brain injury. We investigated 69 patients who were admitted to the Depar tment of Neurosurgery following traumatic brain injury. Both NSE and S-100B serum concentrations during the first three days after admission were high ly and significantly correlated with Glasgow Coma and Coma Remission Scale scores at the respective blood sampling times as well as 2 weeks later. Sig ns of intracranial pathology as evaluated by CCT or MRI scans showed no ass ociation with NSE or S-100B release patterns. Our data support the hypothes is that NSE and protein S-100B are useful and sensitive neurobiochemical ma rkers for the early clinical outcome of traumatic brain injury.