Patients with severe head injury are prone to pulmonary complications that
result in hypoxemia or hypercarbia, which could worsen their neurological c
ondition. A rational ventilatory approach requires a good knowledge of resp
iratory and neurological pathophysiology. Airway management is of prime imp
ortance in neurological patients. Prophylactic chronic hyperventilation in
head trauma is no longer recommended since it could impair cerebral perfusi
on, although transient hypocarbia could be of benefit to some patients. The
use of low or moderate positive and expiratory pressure levels apparently
improves oxygenation without worsening intracranial pressure. Ventilatory m
anagement should be closely monitored and adjusted to hemodynamic, respirat
ory and neurological status to achieve a good outcome.