Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren

Authors
Chandrasekhar, S Mohapatra, S Yadav, JS
Citation
S. Chandrasekhar et al., Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren, TETRAHEDRON, 55(15), 1999, pp. 4763-4768
Citations number
23
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
15
Year of publication
1999
Pages
4763 - 4768
Database
ISI
SICI code
0040-4020(19990409)55:15<4763:PSOAAA>2.0.ZU;2-T
Abstract
Abbott amino-diol (2S,3R, 4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4-dio l 1, a main structural constituent of the orally active renin inhibitor Zan kiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step. (C) 1999 Elsevier Science Ltd. All rights reserved.