An easy one-step synthesis of 4-alkoxypyrimidines from aliphatic esters and nitriles

Authors
Martinez, AG Fernandez, AH Alvarez, RM Vilchez, MDM Gutierrez, MLL Subramanian, LR
Citation
Ag. Martinez et al., An easy one-step synthesis of 4-alkoxypyrimidines from aliphatic esters and nitriles, TETRAHEDRON, 55(15), 1999, pp. 4825-4830
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
15
Year of publication
1999
Pages
4825 - 4830
Database
ISI
SICI code
0040-4020(19990409)55:15<4825:AEOSO4>2.0.ZU;2-8
Abstract
The reaction of aliphatic esters with aliphatic or aromatic nitriles in the presence of trifluoromethanesulfonic anhydride affords substituted 4-alkox ypyrimidines in good yields. A mechanism of the investigated reaction is pr oposed. (C) 1999 Elsevier Science Ltd. All rights reserved.