Simultaneous pancreas-kidney transplant from living donors has been recentl
y proposed as an effective therapeutic option in selected uremic patients w
ith type I diabetes. We report the first simultaneous pancreas-kidney trans
plant performed between identical twins. Posttransplant, the recipient has
been maintained on low dose cyclosporine to avoid recurrent auto-immune ins
ulitis. At the 1-year follow-up, both donor and recipient are well with nor
mal renal function and excellent glucose control. Simultaneous pancreas-kid
ney transplant between identical twins can be performed successfully using
cyclosporine to prevent recurrent auto-immune insulitis.