E. Machova et al., Ultrasonic depolymerization of the chitin-glucan complex from Aspergillus niger and antimutagenic activity of its product, ULTRASON SO, 6(1-2), 1999, pp. 111-114
Sonication was effective for the depolymerization of carboxymethylated chit
in-glucan complex (CM-CG) isolated from the cell wall of Aspergillus niger.
After 10 min of sonication and subsequent gel filtration, two samples (CM-
CG(I) and CM-CG(II)) with significantly distinct molecular weights (660 kDa
and 19 kDa, respectively) and different nitrogen contents (3.02 and 1.69%)
were obtained. CM-CG(II) with lower M-w was also effective against cycloph
osphamide mutagenicity by oral administration in mice. (C) 1999 Elsevier Sc
ience B.V. All rights reserved.