Enhancement of chromatographic detail using infrared spectra from chromatography infrared spectrometer systems

Working with chromatography/infrared spectroscopy data, the technique of lo cal baseline correction in the calculation of the chromatographic intensiti es from each spectrum is used to provide improved chromatographic detection . The technique reduces chromatographic baseline drift, and produces broad- band (universal) chromatograms with noise levels approaching those obtained from narrow-band specific chromatograms. Chromatograms produced from the r atio of two selected band chromatograms can quickly profile a trend in a ho mologous series of compounds, test a chromatographic peak for compositional uniformity, or show shifts in composition across a polymer chromatographic series. (C) 1994 Elsevier Science B.V. All rights reserved.