In the present study, computer-assisted searches for sequence similarities
were performed with amino acid sequences from mammalian reovirus proteins.
These analysis revealed that many proteins of reovirus are partially simila
r to known viral or cellular proteins. Consensus sequences have been identi
fied that are in accordance with already suspected functions of reovirus pr
oteins. The analysis has also revealed unexpected similarities of some reov
irus proteins with specific classes of proteins which sequences are present
in the databases, This could suggest yet unidentified activities for some
of the reovirus proteins.