RECENT INSIGHTS INTO PLATINUM DRUG-RESISTANCE IN CANCER

Cisplatin and its analogs have become important components of chemothe rapeutic regimens for the treatment of solid tumors, however, their ov erall effectiveness is limited by the emergence of drug-resistant tumo r cells. Resistance to the platinum drugs is multifactorial consisting of mechanisms that prevent the formation of lethal platinum-DNA adduc ts and mechanisms that operate downstream of the drug/target interacti on to promote cell survival. Continued progress in the study of the dr ug resistance phenotype as well as the development of new platinum ana logs may eventually lead to improved therapies and increased survival rates.