GAMMA-SCINTIGRAPHY - AN EVOLVING TECHNOLOGY IN PHARMACEUTICAL FORMULATION DEVELOPMENT - PART 1

Gamma scintigraphy provides a noninvasive method to 'see' the in vivo fate of a pharmaceutical dosage form, The power of the technique is re alized fully by correlating deposition and transit of the delivery sys tem with resulting systemic drug levels. Since their inception 25 year s ago, these methods have evolved into the preferred technology for ev aluation of the in vivo behavior of drug delivery systems. In part one of a two part review, the authors describe general scintigraphic meth ods and provide illustrations that exemplify the use of gamma scintigr aphy for the in vivo evaluation of oral formulations. Part 2 of this a rticle will appear in the July issue of PSTT.