Ga. Digenis et al., GAMMA-SCINTIGRAPHY - AN EVOLVING TECHNOLOGY IN PHARMACEUTICAL FORMULATION DEVELOPMENT - PART 1, PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY, 1(3), 1998, pp. 100-107
Gamma scintigraphy provides a noninvasive method to 'see' the in vivo
fate of a pharmaceutical dosage form, The power of the technique is re
alized fully by correlating deposition and transit of the delivery sys
tem with resulting systemic drug levels. Since their inception 25 year
s ago, these methods have evolved into the preferred technology for ev
aluation of the in vivo behavior of drug delivery systems. In part one
of a two part review, the authors describe general scintigraphic meth
ods and provide illustrations that exemplify the use of gamma scintigr
aphy for the in vivo evaluation of oral formulations. Part 2 of this a
rticle will appear in the July issue of PSTT.